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ea0099oc6.4 | Oral Communications 6: Environmental Endocrinology | ECE2024

1,25-Dihydroxyvitamin D3 reduces adipogenesis and mitigates the bisphenol-A-induced pro-adipogenic effect in mouse 3T3-L1 cell line and human adipose-derived mesenchymal stem cells through miR-27-3p regulation

Provvisiero Donatella , Negri Mariarosaria , Amatrudo Feliciana , Patalano Roberta , Monto Tatiana , Pugliese Gabriella , de Alteriis Giulia , Graziadio Chiara , Colao Annamaria , Pivonello Rosario , Savastano Silvia , Pivonello Claudia

Endocrine-disrupting chemicals, including bisphenol A (BPA) may promote obesity. The role of 1,25-Dihydroxyvitamin D3 (VitD) in counteracting adipogenesis is still a matter of question. Thus, the current study aims to investigate whether and how VitD exposure during adipogenesis could prevent the BPA pro-adipogenic effect in adipocyte models: the mouse pre-adipocytes 3T3-L1 and the human adipose-derived mesenchymal stem cells (hAMSC). 3T3-L1 and hAMSC were treated with VitD (1...

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Endocrine Abstracts

1,25-Dihydroxyvitamin D3 reduces adipogenesis and mitigates the bisphenol-A-induced pro-adipogenic effect in mouse 3T3-L1 cell line and human adipose-derived mesenchymal stem cells through miR-27-3p regulation

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